In the meta-analysis of urticaria, the most significant association, which also has the greatest effect, is between rs56043070[A], a predicted splice-donor variant in GCSAML (formerly C1orf150), (MAF ~ 6–7% in all cohorts; NM_145278.4:c.89+1G>A, Supplementary Data 4) and greater urticaria risk (ORcombined = 1.24, P-valuecombined = 3.6 × 10−44; Table 1, Supplementary Data 1). This evidence concerns the gene GCSAML and urticaria.