For variants at the FCER1A and the STAT6 loci, the allele that associates with lower risk of urticaria also associates with decreased serum IgE levels and both are highly correlated with variants previously reported to associate with serum IgE levels (r2 of 0.87 and 1.00, respectively) (Supplementary Data 7, 8)20,21. Here, IGHE is linked to urticaria.