Still, the fact that the TCA cycle enzymes are the focus of substantial biomedical interest51,52, given the key role of some of them (such as Idh1 and Idh2, but also Mdh2) in cancer biology, suggests that multi-pronged targeting of TCA-cycle-related pathways in neuroinflammation might be a viable translational development. The gene discussed is MDH2; the disease is cancer.