In agreement with these results, a previous study revealed that CFA caused an increase in JAK/STAT3 protein phosphorylation in the model of arthritis (Soliman et al. 2022) and interstitial lung (Yang et al. 2019) while decreasing SOCS3 in arthritis model (Srivastava et al. 2022). Here, STAT3 is linked to arthritic joint disease.