JAK2 and acute kidney injury: Additionally, GAL reduced JAK/STAT3 expression in acute kidney injury (AKI) model through modulation of NF-κB (p65) and IL-6/JAK2/STAT3/SOCS3 signals via α7nAChR (Ibrahim et al. 2018) and in experimental asthma model, α7nAChR exerted promising effects by inhibiting NF-κB/STAT3/SOCS3 signaling.