Joint damage in RA begins with macrophage infiltration and CD4 + T lymphocyte activation inducing various cytokines, such as interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa (NF-ҡB), and free radicals, which cause synovial membrane hyperplasia and increased vascularization (Hemshekhar et al. 2012; Ostrowska et al. 2018). This evidence concerns the gene TNF and rheumatoid arthritis.