Additionally, GAL reduced JAK/STAT3 expression in acute kidney injury (AKI) model through modulation of NF-κB (p65) and IL-6/JAK2/STAT3/SOCS3 signals via α7nAChR (Ibrahim et al. 2018) and in experimental asthma model, α7nAChR exerted promising effects by inhibiting NF-κB/STAT3/SOCS3 signaling. The gene discussed is IL6; the disease is acute kidney injury.