The IL-33/ST2 axis has been implicated in many CNS-related diseases and conditions, including Alzheimer’s disease [37, 38], age-related macular degeneration [39], multiple sclerosis (MS) [40] and EAE [41–43], stroke [44], CNS injury [35, 45, 46], and pain [47]. Here, IL33 is linked to early-onset autosomal dominant Alzheimer disease.