Moreover, pathogenic activation of type 2 immunity in response to harmful environmental stimuli can contribute to the development of diseases/conditions that include asthma, allergic rhinitis, atopic dermatitis, and allergies to drugs and foods [26], while excessive inhibition of cytotoxic type 1 immunity by IL-4- and IL-13-activated macrophages can promote tumor development as well as pathological fibrosis or organ scarring [27]. This evidence concerns the gene IL4 and neoplasm.