Similar to Sting-knockdown, we observed that treatment with C-176 significantly abrogated the anti-tumor effects of PD-L1 blockade therapy in Arih1-WT-OE tumors, together with decreased CD8+ and GzmB+CD8+ T cell infiltration, and reduced expression of ISG genes (Supplementary Fig. 10b–h). This evidence concerns the gene ARIH1 and neoplasm.