Gene set enrichment analysis (GSEA) revealed that the gene sets related to STING pathway were upregulated in Arih1-WT-OE cells compared to Arih1-C355S-OE cells, indicating that Arih1-WT-OE in tumor cells triggers the activation of the STING pathway (Supplementary Fig. 9a). The gene discussed is ARIH1; the disease is neoplasm.