ARIH1 and neoplasm: Compared to 4T1 tumors (ARIH1-Low), treatment of B16-F10 tumors (ARIH1-High) with PD-L1 blockade greatly reduced tumor growth and resulted in a significant survival benefit, consistent with the sensitivity to PD-L1 checkpoint blockade observed clinically in patients with advanced melanoma21, 22 (Supplementary Fig. 7b, c).