Moreover, we observed that interferon-stimulated genes (ISGs) including Ifnb1, Ifna2, Il-6, and Ccl5, which have been shown to promote the recruitment of CD8+ T lymphocytes into tumor sites23–25, were significantly increased in Arih1-WT-OE tumor lysates (Fig. 3a, b), indicating that the activated STING pathway in Arih1-WT-OE tumors might be responsible for the establishment of CD8+ T cell “inflamed” microenvironment. Here, CCL5 is linked to neoplasm.