Critically, the cellular, molecular, and metabolic profiling of the engineered cells highlights that MED12 Gly-44 mutation recapitulates major cellular and molecular phenotypes of MED12 mutant UFs tumors, including altered proliferation, fibroid-like transcriptional program, and genomic instability, indicating that the engineered cells faithfully model several molecular features of UFs biology. The gene discussed is MED12; the disease is Ochoa syndrome.