KO models on CAMK2D, PRKD1, MAPK3, NAE1, SLC39A8, PHIP, RFX4, SCARB1, and TNXB showed phenotypes such as myocardial abnormalities, dilated cardiomyopathy, abnormal response to cardiac infarction, and cardiac hypertrophy, suggesting an intrinsic role in heart function regulation (Supplementary Data 16). Here, NAE1 is linked to cardiac hypertrophy.