Five variants had the largest number of associations with HF risk factors: rs9352691/PHIP (blood pressure, body mass index (BMI), high-density lipoprotein cholesterol (HDL-C), alcohol consumption, and atrial fibrillation (AF)), rs12992672/TMEM18 (BMI, HDL-C, type-2 diabetes mellitus (T2DM), AF, and smoking), rs4755720/ HSD17B12 (BMI, HDL-C, T2DM, and CAD), rs233806/BANK1 (blood pressure, HDL-C, and BMI) and rs959388/PRKD1 (BMI, smoking, and blood pressure), details in Supplementary Data 3. This evidence concerns the gene PHIP and hydrops fetalis.