Except for ENPEP, TNXB, and SIRPA, all the other genes that passed thresholds for MR and colocalization with HF also showed an association (defined as MR p < 1 × 10−4 and colocalization: PP.H4 >0.5) with at least one of the 15 HF risk factors (Fig. 3b and Supplementary Data 7). The gene discussed is TNXB; the disease is hydrops fetalis.