To determine whether these receptors are expressed in mouse DG, we generated two tSNE plots for the receptors and found that, while Lrp2 is not expressed, Slc22a17 is expressed in several cell types, including astroglia (Fig. 4e and Supplementary Fig. 4h), suggesting that Lcn2 can act via an auto/paracrine signaling as Lcn2 is upregulated in AD mice in astroglia concomitant to the reactive gliosis (Fig. 4h). Here, LCN2 is linked to Alzheimer disease.