Their expression heatmap indicated that in human AD brains, WDR53, GADD45B, and GLN3 are downregulated while C4B, PFKP, S100A6, and SELENOP are upregulated (Fig. 7c), while Ngfr transduction in mouse hippocampus or amyloid toxicity in adult zebrafish brain changed these genes in opposite directionality (Fig. 7c). The gene discussed is C4B; the disease is Alzheimer disease.