In summary, this study shows that the variable shear factor QKI regulates two key circRNAs, hsa_circ_0006646 and hsa_circ_0061395, and downstream related miRNAs can relieve the targeted inhibition of EMT-related genes (IL11, MFAP2, MMP10, MMP1) and promote the occurrence and development of oesophageal cancer, providing a new theoretical basis for screening prognostic markers of oesophageal cancer patients. Here, MMP1 is linked to carcinoma of esophagus.