CircRUNX1 mediated by insulin-like growth factor 2 mRNA binding protein 2 can promote the progression of ESCC by regulating the miR-449b-5p/FOXP3 axis, and circRUNX1 has the potential to become a diagnostic marker and therapeutic target for ESCC patients [37]. This evidence concerns the gene IGF2BP2 and esophageal squamous cell carcinoma.