MMP1 and carcinoma of esophagus: Thus far, we reached the following conclusion: in oesophageal cancer, the variable shear factor QKI can promote hsa_ circBACH1_ 012, and hsa_circ_0061395 generation, and these circRNAs further competitively bind miRNAs to remove the targeted inhibition of IL11, MFAP2, MMP10 and MMP1 and finally promote the EMT process (Fig 4C).