Thus far, we reached the following conclusion: in oesophageal cancer, the variable shear factor QKI can promote hsa_ circBACH1_ 012, and hsa_circ_0061395 generation, and these circRNAs further competitively bind miRNAs to remove the targeted inhibition of IL11, MFAP2, MMP10 and MMP1 and finally promote the EMT process (Fig 4C). This evidence concerns the gene MMP10 and carcinoma of esophagus.