MMP1 and carcinoma of esophagus: Based on the above findings, we speculate that QKI may promote the occurrence and development of oesophageal cancer by regulating 19 miRNAs downstream of hsa_circ_0006646 and 6 miRNAs downstream of hsa_circ_0061395 to relieve the targeted inhibition of EMT-related genes (IL11, MFAP2, MMP10, MMP1).