AOAH and Sepsis: It has been demonstrated that LPS can be detoxified directly through acyloxyacyl hydrolase (AOAH) dependent enzymatic degradation by several phagocytic cell types and lysosome‐mediated degradation by macrophages or dendritic cells.[22, 23] Thus, we hypothesized that LPS neutralization combined with LPS detoxification would greatly benefit the treatment of sepsis.