The results showed that HCT8‐OR and HT29‐OR‐bearing mice did not respond to oxaliplatin; however, when CDK1 was knocked out, the tumor mass was significantly reduced following oxaliplatin treatment, which was further verified by IHC staining of the Ki‐67 (a proliferation marker) (Figure 2M–R). This evidence concerns the gene MKI67 and neoplasm.