The aim of this study was to investigate the prognostic and predictive role of FoxP3 + regulatory TILs, CD8 + cytotoxic TILs in the tumor margin (CD8 + mTILs), and the ratios of CD8 + mTILs with FoxP3 + TILs and TAMs in a material of 139 non-metastatic HER2 + breast cancer patients. This evidence concerns the gene ERBB2 and breast carcinoma.