However, in HER2 + Luminal B breast cancer, a high FoxP3 + TIL count did associate with a shorter DFS, whereas there were no statistically significant associations in the HER2 + /HR- subgroup. Indeed, it has been suggested that the prognostic role of FoxP3 + and CD8 + TILs may be influenced by HR-status [10, 26, 29]. This evidence concerns the gene FOXP3 and breast cancer.