SOD1 and hypertensive disorder: Oxidative stress is involved in the pathogenesis of HTN and reflects an imbalance between free radicals (reactive oxygen species (ROS), e.g., superoxide, hydrogen peroxide, and hydroxyl radical) and antioxidants (e.g., superoxide dismutase (SOD), catalase (CAT), peroxidases, glutathione, and thioredoxin) [28].