Hence, in agreement with previous studies, two patients with adjacent organs invasion (15.4%), two and four patients occurred lymph node metastasis (15.4%) and intrahepatic metastasis (30.7%), respectively, in our study, maybe partially owing to the CDKN2A mutation [5, 15, 17]. This evidence concerns the gene CDKN2A and metastatic malignant neoplasm in the lymph nodes.