Of the 1555 proteins ranked in the top 10 for ZAK phosphorylation (27), 222 were also identified in our study, including proteins associated with myofibrillar myopathies such as FLNC, BAG3 (BCL2-binding athanogene 3) and TTN (Titin) (Supplementary Material, Fig. S5B and Supplementary Material, Table S5). Here, FLNC is linked to myopathy.