SIX1 and colonic neoplasm: Interestingly, liver, breast, and colon cancer tissues exhibiting high expression levels of SIX1 are very common, indicating that SIX1 upregulation may be associated with cancers with high mortality rates.2 Thus, the analysis of SIX1 expression levels was further investigated using expO datasets for tumor tissues of the liver, breast, and colon histopathological types, which were grouped according to the pathological stage.