SIX1 and hepatocellular carcinoma: Thus, the upregulation of SIX1 expression levels appears to be important for liver, colon, and breast cancers, which are all placed in the top 5 cancers responsible for cancer-related mortalities.2 The findings of the present study are consistent with previous studies, and the reported SIX1 overexpression in our in silico and in vivo data suggested that SIX1 may be important for HCC progression.