Moreover, RNA-Seq analysis of lesional CTCL skin revealed activated signaling pathways in CTCL compared with HD, including NF-κB and JAK/STAT signaling (Figure 4E), and highlighted upregulation of JAK3 (P < 0.0001) and NF-κB (P < 0.0001) genes with highest expression in tumor lesions compared with HD (Figure 4F). Here, JAK3 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.