We found that the CD163+ M2-like TAMs in lesional skin of CTCL were positive for PD-1 expression, and the number of PD-1+CD163+ cells was significantly higher than in healthy controls, suggesting that PD-1+CD163+ M2 phenotypes have important roles in the development of CTCL. The gene discussed is CD163; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.