Based on the above information, we questioned whether LKB1 could therefore be an important, yet unexplored, upstream player in progressive muscle-wasting related to the metabolic sufferance and intolerance to mechanical stress observed in Duchenne muscular dystrophy (DMD), as a consequence of the main primary defect, i.e. the absence of dystrophin (Duan et al., 2021; Gao and McNally, 2015). This evidence concerns the gene DMD and Duchenne muscular dystrophy.