Two commonpesticides, rotenone and paraquat, are known to induce PD-associatedphenotypes in cell culture and model organisms, including oxidativestress, mitochondrial dysfunction, and dopaminergic cell death,136 with rotenone also directly oxidizing PARK7/DJ-1.137 The effects of both rotenone and paraquat arerescued by PARK7 overexpression, indicating that the PARK7 activitydetermines sensitivity to these pesticides.88,138−141 This further suggests that propachlor exposure could potentiatesensitivity to rotenone, paraquat, and other proparkinsonism toxins. The gene discussed is PARK7; the disease is Parkinson disease.