PPARγ is implicated both in several vascular conditions such as atherosclerosis and hypertension and TZDs lower blood pressure in humans and exert protective vascular effects through largely unknown mechanisms (Lalloyer and Staels, 2010; Usuda and Kanda, 2014; Fang, et al., 2021) (Figure 1). The gene discussed is PPARG; the disease is Hypertension.