CSF1R and Alzheimer disease: Notably, adoptive transfer of young WT, and moreover, ACE10/10 bone marrow (BM)-derived CD115+ monocytes to the peripheral blood of AD+ mice, enhanced their recruitment to cerebral Aβ lesion sites, reduced parenchymal and vascular amyloidosis, and restored synaptic integrity (Koronyo-Hamaoui et al., 2020).