CSF1R and Alzheimer disease: Barnes Maze tests comparing diseased AD+ mice with blood enrichment of either CD115+-ACE10/10 or CD115+-ACEWT/WT monocytes, and healthy WT controls demonstrated preservation of spatial learning and memory capacity in AD+ mice following CD115+-ACE10/10 monocyte adoptive transfer, with virtually no difference compared to the healthy WT mice of similar age (Figure 1M).