Studies have shown that H2S increases the expression of VEGF and Ang-1 and enhances angiogenesis in the peri-infarct region by promoting the phosphorylation of AKT and ERK to restore reperfusion and improve neurological function after ischemic stroke in a rat middle cerebral artery occlusion (MCAO) model (Zicola et al., 2021). This evidence concerns the gene AKT1 and ischemic stroke.