Studies have indicated that the Buyang Huanwu Decoction stimulates VEGF and VEGFR2 expression by increasing the expression of caveolin-1, increasing ERK phosphorylation, regulating EC angiogenic activity, and stimulating angiogenesis through the Cav-1/VEGF/ERK signaling pathway and protects the heart muscle in mice with myocardial infarction (Zhu et al., 2019). This evidence concerns the gene MAPK1 and myocardial infarction.