By constructing a mouse model of myocardial infarction, Wen et al. (2022) found that transient receptor potential canonical 1 (TRPC1) is a crucial factor in EC function and angiogenesis and that TRPC1 expression induced by HIF-1α was upregulated in myocardial infarction (MI) mice, thereby regulating the ERK signaling pathway. This evidence concerns the gene TRPC1 and myocardial infarction.