AKT1 and ischemic stroke: Studies have indicated that Salvia miltiorrhiza polyphenolic acid B can increase the number of cerebrovascular ECs; promote the generation of EC tubular structures; increase the expression of angiogenesis-related markers VEGFA, VEGFR2, ANGPT1, ANGPT2, and Tie2; and further upregulate the phosphorylation levels of p-AKT and p-ERK1/2, thus promoting the angiogenic effects of ECs (Li, 2020) and restoring blood flow after ischemic stroke.