By establishing a model of surgically induced acute hindlimb ischemia in diabetic rats, Pan et al. (2013) found that the upregulation of fibroblast growth factor (FGF)-2 and FGFR1 expression activates the ERK1/2 pathway and promotes angiogenesis and ischemic reperfusion (Figure 5). This evidence concerns the gene FGF2 and ischemia.