TP53 and Treacher-Collins syndrome: Treacher-Collins syndrome, another ribosomopathy caused by autosomal dominant mutations of the Tcof1 gene, leads to a deficiency in ribosome synthesis and a p53-dependent apoptosis in neural crest cells of embryos, leading to craniofacial birth defects (Sakai and Trainor, 2009; Trainor et al., 2009), which can be rescued by knocking out p53 (Jones et al., 2008).