For example, the genes MCPH1, ASPM (MCPH5), CENPJ (MCPH6), WDR62 (MCPH2), and CDK5RAP2 (MCPH3) are among the genes with the highest gda score (DisGeNET) and Relevance score (GeneCards), indicating their significant association with microcephaly as evidenced by a large number of publications referenced in both databases (Supplementary Table S1). Here, ASPM is linked to microcephaly.