In contrast, abundant tumor infiltration by immunosuppressive CD4+ CD25+ Foxp3+ regulatory T (Treg) cells, exhaustion CD8+ T cells (expressing PD1, Tim3, and/or Lag3), immature or tolerant DCs, anti-inflammatory M2 like TAMs, and/or myeloid-derived suppressor cells (MDSCs) are generally associated with limited sensitivity to therapy (Bruni et al., 2020; Petroni et al., 2022). This evidence concerns the gene CD4 and neoplasm.