Pancreatic ductal adenocarcinoma (PDA), another type of tumor, is characterized as inherently at immune suppressive status, Nina Frey et al. performed CRISPRko screens in vitro and in vivo to systematically analyze the intrinsic mechanism of PDA cells escaping from CD8+ T cell killing, identified Vps4b and Rnf31 as essential factors for tumor evasion from CD8+ T-cell killing (Frey et al., 2022). The gene discussed is RNF31; the disease is neoplasm.