Some of these mutations are directly responsible for the disease induction because they are inherited from parents with infected children and are known as mutated familial ALS genes including SOD1, TARDBP, FUS, OPTN, VCP, UBQLN2, C9ORF72, ANG, SETX, and SQSTM1 (18, 19). Here, TARDBP is linked to amyotrophic lateral sclerosis.