Sometimes there may be changes in both the anterior pituitary gonadotrophs and the gonads resulting from the original pathology, but it is quite difficult to differentiate these two situations, as in hypogonadotropic hypogonadism, there are changes in the gonads as well due to the loss of stimulatory effect on the gonads by LH and FSH. This evidence concerns the gene BRD2 and hypogonadotropic hypogonadism.