ESR1 and neoplasm: Relationships also exist between the expression of receptors by tumor cells and the neovascularization of EA tissue4–6: MVD growth was observed alongside overexpression of vascular endothelial growth factor (VEGF)5,6,12, hypoxia-inducible factor 1α, and glucose transporter-112, as well as in tumors negative for ER, PR, or both4.