Unbalanced translocation der (5; 17) resulting in a TP53 loss [14], whole-arm translocation of der (5; 17)(p10; q10) with concurrent TP53 mutations [15] and reccuring abnormality dic (5; 17) associated also with mutations of TP53 [16] were described in AML. The gene discussed is TP53; the disease is acute myeloid leukemia.