In few cases with a morphological diagnosis of APL, patients have variant chromosome translocations, which fuse RARA gene with partner genes other than PML, such as in the variant translocation t (5; 17) (q35; q21) that fuses the N-terminus of nucleophosmin (NPM1) gene at 5q35 to the retinoic acid receptor alpha at 17q21 [11, 12]. The gene discussed is NPM1; the disease is acute promyelocytic leukemia.