TET2 and neoplasm: Loss of TET2 leads to DNA hypermethylation at enhancer elements, silencing of tumor suppressor genes, and drug resistance.36 TET2 causes transcriptional repression of IL-6, an important inflammatory mediator in the tumor microenvironment. Increased levels of IL-6 have been shown to promote multi-drug resistance by activating various pathways implicated in cell cycle regulation and proliferation.(17, 24)