IL-17 can promote tumor angiogenesis by inducing angiogenic factors CXCL8, MMP-2, MMP-9, and VEGF (26), it can direct the TME towards an immunosuppressive one by inhibiting apoptosis through NF-κB pathway activation (27) and by inducing the polarization of neutrophils towards a CD8+ T cell-suppressive phenotype (28). This evidence concerns the gene IL17A and neoplasm.