STING1 and neoplasm: Several attempts have been implemented to turn cold tumors into hot, including the activation of the innate immune system using stimulators of interferon genes (STING) agonists, increasing cross-presentation of DCs to promote tumor-antigen-specific T cell infiltration into the TME, targeting the cellular metabolism or transferring within the TME certain metabolites to reduce Tregs, MDSCs or TAMs infiltration (80) as presented in Figure 2.