Univariate Cox analysis was performed on 33 key genes, and the results showed that 10 genes (IL12RB1, IL2RB, IFNG, FASLG, CXCL9, CXCL13, GBP2, CXCL10, CXCR6, and CIITA) had a significant relationship with the prognosis of CRC (P< 0.05). The gene discussed is GBP2; the disease is colorectal carcinoma.