PBRM1 and nonpapillary renal cell carcinoma: Besides the 3p deletion, TCGA analysis confirmed a frequent occurrence in chromosome 5 (67%) and chromosome 14q (45%) deletions, and the top ten mutated genes in ccRCC were VHL, PBRM1, BAP1, SETD2, KDM5C, TP53, mTOR, SMARCA, PTEN, and ARID1A (5, 6).