TP53 and cancer: In addition to the oncogenes mutations mentioned above, mutations of TP53 as one of the most common tumor suppressor gene mutations associated with resistance to cancer therapy.40,41 Having a role as the guardian of the genome, the TP53 gene maintains the integrity of the genome by modifying, stabilizing, and preventing cell proliferation in response to cellular stress.42–45 This study found five subjects with TP53 mutations and showed a shorter survival rate in both OS and PFS.