ACR and infection: Infection with a CRISPR-targeted phage in the presence of P. aeruginosa prophage was monitored using a functional test (Jooyoung et al., 2018), Bioinformatic linkages with known aca genes and Acr proteins “guilt by association”, self-targeting within the same genome, were used in bioinformatic investigations to identify latent Acr candidates in prophages.