In addition, it appears that pravastatin in our study has a clear effect on reducing vascular and blood cell shedding that is independent of its effects on cholesterol levels because even though the administration of statins decreased the total cholesterol and the ApoB/ApoA-I ratio, no correlation was found between the plasma levels of dyslipidemia markers and the concentration of LEVs. The gene discussed is APOB; the disease is metabolic syndrome.