Along with its role in the viral cell entry, the TMPRSS2 activity also influences the Interferon-induced transmembrane protein 3 (IFITM3), which has an important role in the control of SARS-CoV-2 infection given its role in other viral diseases along with its interaction with the S protein (Shi et al., 2021; Dobrijevic et al., 2022). This evidence concerns the gene IFITM3 and viral infectious disease.