The antiproliferative, cytotoxic, antimutagenic, and anticancer phytochemical substances are abundant in medicinal plants (Martínez-Aledo et al., 2020) and might be acting by regulating p53 levels, these extracts have been shown to decrease proliferation and tumor angiogenesis, induce apoptosis, and block the proliferation of tumor cells at several phases, including G2/M, G1/S, S phase, G0/G1, and G1 phase (Aiello et al., 2019). This evidence concerns the gene TP53 and neoplasm.