For instance, in acute myeloid leukemia (AML), the Kv11.1 (hERG1) associates with β1 integrin and the vascular endothelial growth factor (VEGF) receptor 1 (also known as Flt-1), to form a complex that modulates the cell proliferation and trans-endothelial migration signaling pathways (Pillozzi et al., 2007). This evidence concerns the gene FLT1 and acute myeloid leukemia.