This is in agreement with a recent paper demonstrating that SK2 channel, expressed in pancreatic ductal adenocarcinoma, increased invasiveness and metastasis formation, an effect that depends on cancer-associated fibroblasts (CAF) promoting SK2 phosphorylation through an integrin–epidermal growth factor receptor (EGFR)–AKT (Protein kinase B) axis (Rapetti-Mauss et al., 2022). This evidence concerns the gene AKT1 and pancreatic ductal adenocarcinoma.