While T1DM did not affect M2AChR expression, ChAT overexpression significantly increased the expression of M2AChR at 8, 12 and 16 weeks post T1DM induction compared with wild type, and specifically at 16 weeks compared with T1DM (Fig. 1G& Supplemental Fig. 5). The gene discussed is CHAT; the disease is type 1 diabetes mellitus.