IDH mutant glioma patients have increased levels of DNA methylation,357, 358 resulting in ectopic interaction between the enhancer located 50 kb upstream of FIP1L1 and the proto‐oncogene PDGFRA promoter, leading to a three‐fold increase in the expression level of proto‐oncogene PDGFRA and promoting glioma cell proliferation.359. This evidence concerns the gene FIP1L1 and central nervous system cancer.