The therapeutic action of anti-CD47 antibody alone or in combination with rituximab is predominantly mediated by macrophage phagocytosis, and macrophage depletion abolished the synergistic impact of anti-CD47 antibody in conjunction with rituximab, emphasizing the significance of macrophages as effectors of anti-CD47 antibody treatment in human non-Hodgkin lymphoma (65). The gene discussed is CD47; the disease is non-Hodgkin lymphoma.