As CD40 is also overexpressed in CLL and MM, the bsAb CD40-Vγ9Vδ2 T cell engager (LAVA-1278) was shown as promoting a potent Vδ2 T cell degranulation and cytotoxicity against CLL and MM cells in vitro and in vivo (75). This evidence concerns the gene CD40 and B-cell chronic lymphocytic leukemia.