CD8A and neoplasm: In another study of ten tumor samples of infantile fibrosarcoma demonstrated markedly higher CD4+ and CD8+ T cell infiltration (40-50x) compared to age- and sex-matched rhabdomyosarcoma tumor samples, and fusion negative tumors contained a much higher fraction of activated CD8+ T cells (74), and rhabdomyosarcoma samples generally exhibit low CD3+ lymphocyte frequency with predominant macrophages, which correlate with improved event-free and overall survival (75), though tertiary lymphoid structures do form in rhabdomyosarcoma tumors (76).