Intracellular delivery of cGAMP, the activating molecule for STING and IFN gene activation, increased release of damage associated molecular pattern (DAMP) molecules and pro-inflammatory cytokines CXCL10, IL-12, IFN-β and TNF-α, as well as decreased the Treg cell population and increased the CD8+ T cell fraction, leading to slowed tumor growth and improved OS in a syngeneic murine model of NBL. Here, CD8A is linked to neoplasm.