Tumor cells can induce suppressive-type TAMs with suppressive cytokine production (IL-10, TGF-β and CCL22) which can be reversed with TGF-β blockade (83) and hepatocyte growth factor blockade improves infiltration of a GD2-targeted CAR-T cell construct (84), suggesting that the tumor cells regulate immune cell infiltration and phenotypic differentiation within the TME. The gene discussed is TGFB1; the disease is neoplasm.