It should be noted that all the altered genes in the 5h ischemia hearts compared to the 1h ischemia group (ccl2, Icam1, Fos, Txnrd1, Hspa1a, and Tlr4) were not found after AAT treatment (5h ischemia+AAT vs. 5h ischemia). The gene discussed is SERPINA1; the disease is ischemia.