Among them, IL-1β, IL-6, IFNγ and IFNγ-induced chemokines, such as CXCL9, CXCL10, and CXCL11, were investigated for monitoring patients with MAS complicating sJIA through Luminex multiplexing technology (multiplexing ELISA assay). This evidence concerns the gene CXCL9 and macrophage activation syndrome.