TMEM123 and colorectal carcinoma: We first investigated TMEM123 expression in CRC by immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) tissue microarrays (TMAs) representing CRC and paired non-malignant adjacent tissues (NAT) (referred as TMA1, Table S1), using TMEM123-transfected and mock HEK293T cells as positive and negative staining controls (Figure S1A).