This study also shows that TMEM123 is important for T cell adhesion, chemotaxis and trans-endothelial migration, as assessed by transmigration in vitro assays, where we observed an active migration of TMEM123+ CD8+T lymphocytes towards soluble factors present in cancer cells conditioned medium, known to be enriched both in growth factor and in migration-inducing chemokines, which was strongly inhibited by TMEM123 silencing. Here, CD8A is linked to cancer.