TMEM123 expression was found in both tumor-infiltrating CD8+ (19% ± 3%) and CD4+ (11% ± 2%) T cells, while it was almost undetectable in T lymphocytes isolated from normal tissues (2.7% ± 0.5%) or PBMCs (0.9% ± 0.2%). Here, TMEM123 is linked to neoplasm.