TMEM123 and cancer: Quantification of merged fluorescence signals for TMEM123, CD4 and CD8, in the 83 tested primary tumors confirmed a higher TMEM123+ expression in CRC-infiltrating CD4+ and CD8+ T lymphocytes compared to normal colon lymphocytes, while the frequency of TMEM123+ TILs in cancer and corresponding metastases was similar (Figures 2B, S2).