ITGAM and neoplasm: To investigate if Ly6CloMHC-IIlo nonclassical monocytes are able to load tumor-specific antigen onto MHC-I complexes for cross-presentation to CD8+ T cells, levels of MHC-I-OVA-SIINFEKL+ cells present amongst circulating CD115+CD11b+ monocytes were quantified (Figure 3F).