CD69 and neoplasm: At 6 days post-tumor cell injection, analysis of the draining medLNs revealed a 1.8-fold increase in the frequency of CD44+CD69+CD8+ T cells, a phenotype associated with early T cell activation, in B16F10-OVA tumor-bearing B6 mice (B16) compared to uninjected B6 mice (Figures 2A, B).