To compare the relationship between classical and nonclassical monocytes with CD8+ T cell activation in the context of human lung cancer, Spearman correlations were performed to evaluate the association between CD8+ T cell activation genes and gene signatures of classical and nonclassical monocytes in adjacent normal lung, lung tumor, and metastatic melanoma lesions utilizing the same publicly available datasets mentioned above (40, 41). This evidence concerns the gene CD8A and lung cancer.