Therefore, to overcome the limitations of individual studies, and resolve inconsistencies, we conducted an all-sided meta-analysis of the association between three SNPs, including rs1990760, rs10930046, and rs3747517, in the IFIH1 gene and multiple AIDs including SLE, T1D, GD, HT, RA, AAD, and MS. The gene discussed is IFIH1; the disease is systemic lupus erythematosus.